The present-day Reformed Deanery of Nagykároly, with its 33 congregations, is located in the southern part of Szatmár County, south of the Kraszna river. It is bordered by the state border to the west, the Érmellék region to the south, and the Szilágyság region to the east. Its current form was established in 1994, when the Szatmári deanery separated from it.

When speaking of Nagykároly, the name of Károli Gáspár inevitably comes to mind. Born in this town under the name Radicsics, he gifted posterity in 1590 with the Vizsoly Bible, the first complete Hungarian translation of the Holy Scriptures. Through this work, he not only provided a foundational religious text but also decisively shaped the development of the Hungarian literary language and culture.